1342 - Modifiable risk factors associated with reduced function and quality of life in patients with non-relapsed multiple myeloma

Prevalence of patients with multiple myeloma has increased in the last several decades, allowing for greater opportunities for complex symptomatic management. Patients with multiple myeloma experience symptoms from both the disease and treatments that can affect function and quality of life. The purpose of this study is to identify factors within the multiple myeloma population that could be modified to promote improved function and quality of life. 

Design:

We conducted a retrospective review of previously collected registry information from patients at our institution. The population included patients with multiple myeloma that had never relapsed and who had data from registry enrollment and at least one assessment at 3, 6 and/or 12 months after enrollment. The self-reported assessments included the Older Americans Resources and Services – Instrumental Activities of Daily Living (OARS-iADL), the European Organization for Research and Treatment of Cancer (EORTC QLQ-C30) and the Karnofsky Performance Scale (KPS). Higher scores indicate better functional status, quality of life, and performance status. Marginal models with generalized estimating equations were used to assess differences in outcomes over time between groups.

Results:

96 patients met inclusion criteria.  Patients who reported rarely engaging in vigorous activity (never to a few times per month) had a significantly lower average scores than those who exercised at least 1-2 times per week for OARS-iADL, EORTC QLQ-C30, and KPS scores at registry enrollment [(12.3 vs. 13.7; p=< 0.0001); (74.3 vs. 85.8; p=< 0.0001); (79.9 vs. 90.1; p = < 0.0001, respectively)]. Patients with a self-reported fall had lower average scores for EOTC QLQ-C30 and KPS at registry enrollment [82.2 vs. 69.4; p = 0.0006) and (86.6 vs. 78.1; p = 0.008)].

Conclusions:

These assessments showed that regular exercise is associated with functional performance and quality of life. Future studies examining the utility of prehabilitation programs for improving these patient-centric outcomes are warranted.