1704 - A Sustainable Wound Environment using Bioactive Glass (BBGFM) Contributes to the Efficacy in Healing Complex Lower Extremity Wounds

Chronic lower extremity wounds often fail to respond to conventional therapy, placing patients at risk for infection, prolonged disability, and potential amputation. Borate bioactive glass fiber matrix (BBGFM) is a synthetic skin substitute composed of natural elements in fiber and microsphere form. It conforms to wound surfaces, supports angiogenesis through VEGF upregulation, and functions as a dissolvable scaffold that promotes granulation and epithelialization. The purpose of this study was to evaluate the clinical effectiveness of BBGFM in promoting healing across a range of complex wound etiologies.

Design:

Ten patients (five males, five females; ages 49–71) with chronic lower extremity wounds were treated with one to three applications of BBGFM. Wound etiologies included delayed post-surgical wounds, diabetic foot ulcers, venous ulcers, a crush injury, and pressure injuries. Sharp debridement was performed as clinically indicated, followed by secondary dressings to maintain a moist wound environment. Further debridement was completed only if necessary. Clinical endpoints included wound area reduction, angiogenesis, granulation, epithelialization, pain levels, exudate control, and presence of infection.

Results:

All wounds demonstrated progressive healing following BBGFM application. Angiogenesis and granulation tissue formation were noted early, often within the first week, with significant wound area reduction observed. Epithelialization occurred in every case. Patients reported decreased pain, improved optimism, and better control of wound drainage. Clinicians cited ease of use and favorable handling characteristics. No infections were reported.

Conclusions:

BBGFM supported angiogenesis, granulation, and epithelialization in complex lower extremity wounds that are typically difficult to heal. These outcomes reinforce existing clinical data supporting its safety and efficacy. By reducing complications and accelerating healing, BBGFM demonstrates potential to improve patient quality of life and optimize clinical outcomes in the management of chronic wounds.